Cognitive outcomes of prenatal antiepileptic drug exposure
نویسندگان
چکیده
منابع مشابه
Prenatal drug exposure: infant and toddler outcomes.
This manuscript provides an overview of the current scientific literature on the impact of maternal drug use, specifically opioids and cocaine, during pregnancy on the acute and long-term outcomes of infants and toddlers from birth through age 3 years. Emphasis with regard to opioids is placed on heroin and opioid substitutes used to treat opioid addiction, including methadone, which has long b...
متن کاملCognitive outcomes of preschool children with prenatal cocaine exposure.
CONTEXT Because of methodological limitations, the results of the few prospective studies assessing long-term cognitive effects of prenatal cocaine exposure are inconsistent. OBJECTIVE To assess effects of prenatal cocaine exposure and quality of caregiving environment on 4-year cognitive outcomes. DESIGN Longitudinal, prospective, masked comparison cohort study from birth (September 1994-J...
متن کاملReduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid.
Prenatal exposure to valproic acid (VPA), an established antiepileptic drug, has been reported to impair postnatal cognitive function in children born to VPA-treated epileptic mothers. However, how these defects arise and how they can be overcome remain unknown. Using mice, we found that comparable postnatal cognitive functional impairment is very likely correlated to the untimely enhancement o...
متن کاملNeuroimaging of prenatal drug exposure.
a Department of Physiology and Pharmacology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Box #29, Brooklyn, NY 11203, USA b Medical Department, Brookhaven National Laboratory, New York, USA c University of Florida, College of Medicine, Department of Pediatrics, Gainesville, Florida, USA d University of Miami School of Medicine, Department of Pediatrics, Miami, Fl...
متن کاملFetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study.
BACKGROUND Many women of childbearing potential take antiepileptic drugs, but the cognitive effects of fetal exposure are uncertain. We aimed to assess effects of commonly used antiepileptic drugs on cognitive outcomes in children up to 6 years of age. METHODS In this prospective, observational, assessor-masked, multicentre study, we enrolled pregnant women with epilepsy on antiepileptic drug...
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ژورنال
عنوان ژورنال: Epilepsy Research
سال: 2015
ISSN: 0920-1211
DOI: 10.1016/j.eplepsyres.2015.04.016